Macrophage migration inhibitory factor: A regulator of innate immunity

被引：1470

作者：

Calandra, T ^{[1
]}

Roger, T ^{[1
]}

机构：

[1] CHU Vaudois, Dept Internal Med, Div Infect Dis, CH-1011 Lausanne, Switzerland

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 10期

关键词：

D O I：

10.1038/nri1200

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.

引用

页码：791 / 800

页数：10

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