The role of endosomes and lysosomes in MHC class II functioning

被引：149

作者：

Geuze, HJ ^{[1
]}

机构：

[1] Univ Utrecht, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(98)01269-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cells, dendritic cells and macrophages present peptides derived from exogenous antigens to CD4(+) T cells. After uptake, antigens are processed into peptides, bound to major histocompatibility complex (MHC) class II molecules and transported to the plasma membrane. Here, Hans Geuze reviews the current controversy surrounding the identity of the compartments that play a role in antigen processing and peptide loading.

引用

页码：282 / 287

页数：6

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