MRI measurement of brain iron in patients with restless legs syndrome

被引：424

作者：

Allen, RP

Barker, PB

Wehrl, F

Song, HK

Earley, CJ

机构：

[1] Johns Hopkins Bayview Med Ctr, Dept Neurol, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Hopkins Sleep Disorders Ctr, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD USA

[4] Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA

来源：

NEUROLOGY | 2001年 / 56卷 / 02期

关键词：

D O I：

10.1212/WNL.56.2.263

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R-2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls), R-2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

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页码：263 / 265

页数：3

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