A gene highly homologous to ACP1 encoding cysteine proteinase 3 in Entamoeba histolytica is present and expressed in E-dispar

被引:18
作者
Bruchhaus, I [1 ]
Tannich, E [1 ]
机构
[1] BERNHARD NOCHT INST TROP MED,D-20359 HAMBURG,GERMANY
来源
PARASITOLOGY RESEARCH | 1996年 / 82卷 / 02期
关键词
D O I
10.1007/s004360050093
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
We have cloned the complete gene encoding cysteine proteinase 3 in E. histolytica as well as a cDNA encoding a highly homologous protein in E. dispar. In addition, we have demonstrated the presence and expression of the CP3 gene in various E. histolytica and E. dispar isolates. Since the expression of the gene is rather similar within both Entamoeba species, we assume that it does not constitute the proposed virulence factor of E. histolytica.
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页码:189 / 192
页数:4
相关论文
共 16 条
[1]   UNUSUAL GENE ORGANIZATION IN THE PROTOZOAN PARASITE ENTAMOEBA-HISTOLYTICA [J].
BRUCHHAUS, I ;
LEIPPE, M ;
LIOUTAS, C ;
TANNICH, E .
DNA AND CELL BIOLOGY, 1993, 12 (10) :925-933
[2]  
BRUMPT E., 1925, Bull. Acad. Med., V94, P943
[3]   A REDESCRIPTION OF ENTAMOEBA-HISTOLYTICA SCHAUDINN, 1903 (EMENDED WALKER, 1911) SEPARATING IT FROM ENTAMOEBA-DISPAR BRUMPT, 1925 [J].
DIAMOND, LS ;
CLARK, CG .
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 1993, 40 (03) :340-344
[4]   ENTAMOEBA-HISTOLYTICA - CORRELATION BETWEEN VIRULENCE AND CONTENT OF PROTEOLYTIC-ENZYMES [J].
GADASI, H ;
KOBILER, D .
EXPERIMENTAL PARASITOLOGY, 1983, 55 (01) :105-110
[5]  
HORSTMANN RD, 1992, TROP MED PARASITOL, V43, P213
[6]   ENTAMOEBA-HISTOLYTICA - CORRELATION OF THE CYTOPATHIC EFFECT OF VIRULENT TROPHOZOITES WITH SECRETION OF A CYSTEINE PROTEINASE [J].
KEENE, WE ;
HIDALGO, ME ;
OROZCO, E ;
MCKERROW, JH .
EXPERIMENTAL PARASITOLOGY, 1990, 71 (02) :199-206
[7]  
LEIPPE M, 1995, IN PRESS PARASITOLOG
[8]   AFFINITY PURIFICATION AND BIOCHEMICAL-CHARACTERIZATION OF HISTOLYSIN, THE MAJOR CYSTEINE PROTEINASE OF ENTAMOEBA-HISTOLYTICA [J].
LUACES, AL ;
BARRETT, AJ .
BIOCHEMICAL JOURNAL, 1988, 250 (03) :903-909
[9]   CLONING OF A VIRULENCE FACTOR OF ENTAMOEBA-HISTOLYTICA - PATHOGENIC STRAINS POSSESS A UNIQUE CYSTEINE PROTEINASE GENE [J].
REED, S ;
BOUVIER, J ;
POLLACK, AS ;
ENGEL, JC ;
BROWN, M ;
HIRATA, K ;
QUE, XC ;
EAKIN, A ;
HAGBLOM, P ;
GILLIN, F ;
MCKERROW, JH .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1532-1540
[10]   THIOL PROTEINASE EXPRESSION AND PATHOGENICITY OF ENTAMOEBA-HISTOLYTICA [J].
REED, SL ;
KEENE, WE ;
MCKERROW, JH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (12) :2772-2777