Phosphoinositide kinases

被引：556

作者：

Carpenter, CL

Cantley, LC

机构：

[1] BETH ISRAEL HOSP,DEPT MED,DIV SIGNAL TRANSDUCT,BOSTON,MA 02215

[2] HARVARD UNIV,SCH MED,DEPT CELL BIOL,BOSTON,MA 02115

来源：

CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(96)80060-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide g-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has identified a number of processes in which phosphoinositide 3-kinase participates, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. Several possible biochemical targets of phosphoinositides have been found.

引用

收藏

页码：153 / 158

页数：6

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