Short-term androgen deprivation therapy for patients with intermediate-risk prostate cancer undergoing dose-escalated radiotherapy: the standard of care?

被引：56

作者：

Zumsteg, Zachary S. ^{[1
]}

Zelefsky, Michael J. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10065 USA

来源：

LANCET ONCOLOGY | 2012年 / 13卷 / 06期

关键词：

EXTERNAL-BEAM RADIATION; BIOCHEMICAL TUMOR-CONTROL; PHASE-III TRIAL; RADICAL PROSTATECTOMY; HORMONAL-THERAPY; DISTANT METASTASES; RANDOMIZED-TRIAL; FOLLOW-UP; CARDIOVASCULAR MORTALITY; CONFORMAL RADIOTHERAPY;

D O I：

10.1016/S1470-2045(12)70084-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

What is the best way to manage patients with intermediate-risk prostate cancer? One of the most controversial aspects of treatment is the role of short-term androgen deprivation therapy in combination with definitive radiotherapy. In two randomised trials of patients with mostly intermediate-risk prostate cancer, increased overall survival was reported when short-term androgen deprivation therapy was added to radiotherapy. However, radiation doses in these studies were far below the current standard of care. This limitation, in combination with the heterogeneous nature of the cancers classified as intermediate risk, has complicated the application of these trial results to modern clinical practice. In this Review, we discuss clinical evidence for and against use of short-term androgen deprivation therapy with dose-escalated radiotherapy for patients with intermediate-risk prostate cancer.

引用

页码：E259 / E269

页数：11

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