Designed membrane channels and pores

被引：76

作者：

Bayley, H ^{[1
]}

机构：

[1] Texas A&M Hlth Sci Ctr, Dept Med Biochem & Genet, College Stn, TX 77843 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0958-1669(99)80017-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in the synthesis and assembly of designed membrane channels and pores include addressable template-assisted synthetic protein (TASP) syntheses of helix bundles, the production of a new class of nanotubes and the ability to purify hetero-oligomeric pores. Channels and pores with altered functional properties and with built-in triggers and switches have been prepared. Progress in applications has been greatest in sensor technology, where sensor elements based on ligand activation, channel selectivity and channel block have been made. Structural information about natural membrane proteins is emerging to inspire new designs.

引用

页码：94 / 103

页数：10

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