共 53 条
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
被引:578
作者:

Almeida, Jorge R.
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Price, David A.
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Papagno, Laura
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Arkoub, Zaina Ait
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h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Sauce, Delphine
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Bornstein, Ethan
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Asher, Tedi E.
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Samri, Assia
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Schnuriger, Aurelie
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Theodorou, Ioannis
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

论文数: 引用数:
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Rouzioux, Christine
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Agut, Henri
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Marcelin, Anne-Genevieve
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Douek, Daniel
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Autran, Brigitte
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Appay, Victor
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France
机构:
[1] INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France
[2] Univ Paris 06, Hop La Pitie Salpetriere, Virol Lab, UPRES EA2387, F-75013 Paris, France
[3] Univ Paris 06, Hop La Pitie Salpetriere, U720, INSERM, F-75013 Paris, France
[4] NIH, Human Immunol Sect, Vaccine Res Ctr, Bethesda, MD 20892 USA
[5] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England
[6] Univ Rene Descartes Paris 5, Virol Lab, Hop Necker Enfants Malad, F-75015 Paris, France
基金:
英国医学研究理事会;
关键词:
D O I:
10.1084/jem.20070784
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The key attributes of CD8(+) T cell protective immunity in human immunodeficiency virus ( HIV) infection remain unclear. We report that CD8(+) T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV- 1 replication in human histocompatibility leukocyte antigen ( HLA) - B27 patients. To understand further the nature of CD8(+) T cell - mediated antiviral efficacy, we performed a comprehensive study of CD8(+) T cells specific for the HLA- B27 - restricted epitope KK10 in chronic HIV- 1 infection based on the use of multiparametric flow cytometry together with molecular clonotypic analysis and viral sequencing. We show that B27- KK10 - specific CD8(+) T cells are characterized by polyfunctional capabilities, increased clonal turnover, and superior functional avidity. Such attributes are interlinked and constitute the basis for effective control of HIV- 1 replication. These data on the features of effective CD8(+) T cells in HIV infection may aid in the development of successful T cell vaccines.
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收藏
页码:2473 / 2485
页数:13
相关论文
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