Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease

被引：124

作者：

Campos-Neto, A

Porrozzi, R

Greeson, K

Coler, RN

Webb, JR

Seiky, YAW

Reed, SG

Grimaldi, G

机构：

[1] Infect Dis Res Inst, Seattle, WA 98104 USA

[2] Corixa Corp, Seattle, WA 98104 USA

[3] Med Sch Itajuba, Itajuba, MG, Brazil

[4] Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil

[5] Univ Ottawa, Fac Med, Ottawa, ON, Canada

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 06期

关键词：

D O I：

10.1128/IAI.69.6.4103-4108.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leishmaniasis affects approximately 2 million people each year throughout the world. This high incidence is due in part to the lack of an efficacious vaccine. We present evidence that the recombinant leishmanial antigens LmSTI1 and TSA, which we identified and characterized previously, induce excellent protection in both murine and nonhuman primate (rhesus monkey) models of human cutaneous leishmaniasis. The remarkable protection induced by LmSTI1 and TSA in an animal model that is evolutionarily close to humans qualifies this antigen combination as a promising candidate subunit vaccine against human leishmaniasis.

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页码：4103 / 4108

页数：6

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