Solution and solid-phase synthesis of potent inhibitors of Hepatitis C Virus NS3 proteinase

被引：26

作者：

Beevers, R ^{[1
]}

Carr, MG ^{[1
]}

Jones, PS ^{[1
]}

Jordan, S ^{[1
]}

Kay, PB ^{[1
]}

Lazell, RC ^{[1
]}

Raynham, TM ^{[1
]}

机构：

[1] Roche Discovery Welwyn, Dept Chem, Welwyn Garden City AL7 3AY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)00816-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A versatile route for the synthesis of homochiral alpha-ketoamide analogues of amino acids is described. Incorporation of this functionality into peptide sequences using either solution or solid-phase chemistry resulted in potent inhibitors of the Hepatitis C Virus NS3 proteinase, (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：641 / 643

页数：3

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