The identification of α-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase

被引：38

作者：

Bennett, JM

Campbell, AD

Campbell, AJ

Carr, MG

Dunsdon, RM

Greening, JR

Hurst, DN

Jennings, NS

Jones, PS

Jordan, S

Kay, PB

O'Brien, MA

King-Underwood, J

Raynham, TM

Wilkinson, CS

Wilkinson, TCI

Wilson, FX ^{[1
]}

机构：

[1] Roche Discovery Welwyn, Dept Chem, Welwyn Garden City AL7 3AY, Herts, England

[2] Roche Discovery Welwyn, Dept Viral Dis, Welwyn Garden City AL7 3AY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00654-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptides based upon the non-prime side residues of the NS4A-4B cleavage site of hepatitis C virus (HCV) NS3-4A proteinase containing an alpha -ketoamide moiety in place of the scissile amide bond are potent inhibitors of this enzyme. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：355 / 357

页数：3

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