Regulation of transcription of MHC class II genes

被引：175

作者：

Boss, JM

机构：

[1] Dept. of Microbiology and Immunology, Emory Univ. Sch. Med., 3131 R., Atlanta

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(97)80166-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-gamma.

引用

收藏

页码：107 / 113

页数：7

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