Cancer drug resistance: an evolving paradigm

被引：3653

作者：

Holohan, Caitriona ^{[1
]}

Van Schaeybroeck, Sandra ^{[1
]}

Longley, Daniel B. ^{[1
]}

Johnston, Patrick G. ^{[1
]}

机构：

[1] Queens Univ Belfast, Drug Resistance Grp, Ctr Canc Res & Cell Biol, Belfast BT9 7BL, Antrim, North Ireland

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 10期

关键词：

CELL LUNG-CANCER; CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; TYROSINE KINASE INHIBITORS; BH3 MIMETIC ABT-737; DNA MISMATCH REPAIR; BCR-ABL INHIBITOR; MULTIDRUG-RESISTANCE; ACQUIRED-RESISTANCE; TARGETED THERAPY;

D O I：

10.1038/nrc3599

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing current cancer research. The mechanisms of resistance to 'classical' cytotoxic chemotherapeutics and to therapies that are designed to be selective for specific molecular targets share many features, such as alterations in the drug target, activation of prosurvival pathways and ineffective induction of cell death. With the increasing arsenal of anticancer agents, improving preclinical models and the advent of powerful high-throughput screening techniques, there are now unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive biomarkers to enable patient stratification.

引用

页码：714 / 726

页数：13

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