Diversity of microRNAs in human and chimpanzee brain

被引：382

作者：

Berezikov, Eugene

Thuemmler, Fritz

van Laake, Linda W.

Kondova, Ivanela

Bontrop, Ronald

Cuppen, Edwin

Plasterk, Ronald H. A.

机构：

[1] KNAW, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

[2] Vertis Biotechnol AG, D-85354 Freising Weihenstephan, Germany

[3] Univ Utrecht, Med Ctr, Dept Cardiol, NL-3508 GA Utrecht, Netherlands

[4] Biomed Primate Res Ctr, Rijswijk, Netherlands

来源：

NATURE GENETICS | 2006年 / 38卷 / 12期

关键词：

D O I：

10.1038/ng1914

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

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收藏

页码：1375 / 1377

页数：3

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