Gene regulation by microRNAs

被引：393

作者：

Carthew, RW ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2006年 / 16卷 / 02期

关键词：

D O I：

10.1016/j.gde.2006.02.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in animal development and physiology. Cellular activities such as proliferation, morphogenesis, apoptosis and differentiation are regulated by microRNAs. The expression of various genes are regulated by microRNAs, and several microRNAs act in reciprocal negative feedback loops with protein factors to control cell fate decisions that are triggered by signal transduction activity. These observations implicate small RNAs as important mediators of gene regulation in response to cell-cell signaling. The mechanism by which microRNAs silence gene expression is post-transcriptional, possibly influencing the stability, compartmentalization and translation of mRNAs. This mechanism is an efficient means to regulate production of a diverse range of proteins.

引用

页码：203 / 208

页数：6

共 46 条

[1] The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans [J].

Abbott, AL ;

Alvarez-Saavedra, E ;

Miska, EA ;

Lau, NC ;

Bartel, DP ;

Horvitz, HR ;

Ambros, V .

DEVELOPMENTAL CELL, 2005, 9 (03) :403-414

[2] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation [J].

Bagga, S ;

Bracht, J ;

Hunter, S ;

Massirer, K ;

Holtz, J ;

Eachus, R ;

Pasquinelli, AE .

CELL, 2005, 122 (04) :553-563

[3] Principles of MicroRNA-target recognition [J].

Brennecke, J ;

Stark, A ;

Russell, RB ;

Cohen, SM .

PLOS BIOLOGY, 2005, 3 (03) :404-418

[4] Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].

Cai, XZ ;

Hagedorn, CH ;

Cullen, BR .

RNA, 2004, 10 (12) :1957-1966

[5] TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing [J].

Chendrimada, TP ;

Gregory, RI ;

Kumaraswamy, E ;

Norman, J ;

Cooch, N ;

Nishikura, K ;

Shiekhattar, R .

NATURE, 2005, 436 (7051) :740-744

[6] Processing of primary microRNAs by the Microprocessor complex [J].

Denli, AM ;

Tops, BBJ ;

Plasterk, RHA ;

Ketting, RF ;

Hannon, GJ .

NATURE, 2004, 432 (7014) :231-235

[7] Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters rnicroRNA levels, and enhances global protein synthesis [J].

Dresios, J ;

Aschrafi, A ;

Owens, GC ;

Vanderklish, PW ;

Edelman, GM ;

Mauro, VP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (06) :1865-1870

[8] MicroRNAs regulate brain morphogenesis in zebrafish [J].

Giraldez, AJ ;

Cinalli, RM ;

Glasner, ME ;

Enright, AJ ;

Thomson, JM ;

Baskerville, S ;

Hammond, SM ;

Bartel, DP ;

Schier, AF .

SCIENCE, 2005, 308 (5723) :833-838

[9] The Microprocessor complex mediates the genesis of microRNAs [J].

Gregory, RI ;

Yan, KP ;

Amuthan, G ;

Chendrimada, T ;

Doratotaj, B ;

Cooch, N ;

Shiekhattar, R .

NATURE, 2004, 432 (7014) :235-240

[10] Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C-elegans developmental timing [J].

Grishok, A ;

Pasquinelli, AE ;

Conte, D ;

Li, N ;

Parrish, S ;

Ha, I ;

Baillie, DL ;

Fire, A ;

Ruvkun, G ;

Mello, CC .

CELL, 2001, 106 (01) :23-34

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