MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

被引：520

作者：

van Rooij, Eva ^{[2
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[2] MiRagen Therapeut, Boulder, CO 80301 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2012年 / 11卷 / 11期

关键词：

IN-VIVO; COLLAGEN EXPRESSION; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; RENAL FIBROSIS; MESSENGER-RNAS; UP-REGULATION; HUMAN HEART; CELL; INHIBITION;

D O I：

10.1038/nrd3864

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the pharmacokinetic and pharmacodynamic properties of current antimiR designs and their relevance to cardiovascular indications, and evaluate the opportunities and obstacles associated with this new therapeutic modality.

引用

页码：860 / 872

页数：13

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