Bcl-2 gene family in the nervous system

被引：527

作者：

Merry, DE

Korsmeyer, SJ

机构：

[1] WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST,DIV MOL ONCOL,DEPT MED,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST,DIV MOL ONCOL,DEPT PATHOL,ST LOUIS,MO 63110

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 1997年 / 20卷

关键词：

apoptosis; neuronal cell death; neurodegeneration; Bcl-x;

D O I：

10.1146/annurev.neuro.20.1.245

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A growing family of genes that share homology with the bcl-2 proto-oncogene is involved in the regulation of cell death. Many of these proteins show widespread expression and are expressed in the nervous system in developing and adult organisms. A physiologic role for Bcl-2 and Bcl-x in neuron survival has been shown. In addition, these proteins have been shown to protect neurons from a wide array of toxic insults. In this review, we discuss the Bcl-2 family of proteins with regard to their structure and interactions. We then discuss the role of apoptotic cell death in the development of the nervous system and as a response to neuronal injury. Lastly, we discuss the evidence for a role for these cell death regulators in neuronal death decisions.

引用

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页码：245 / 267

页数：23

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