The role of cytoskeleton in the regulation of vascular endothelial barrier function

被引：156

作者：

Bogatcheva, Natalia V. ^{[1
]}

Verin, Alexander D. ^{[1
]}

机构：

[1] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA

来源：

MICROVASCULAR RESEARCH | 2008年 / 76卷 / 03期

关键词：

Cytoskeleton; Endothelial; Barrier function; Permeability;

D O I：

10.1016/j.mvr.2008.06.003

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：202 / 207

页数：6

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