The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

被引：102

作者：

Kikuchi, Kiyoshi ^{[1
,2
,3
]}

Tancharoen, Salunya ^{[1
]}

Takeshige, Nobuyuki ^{[3
]}

Yoshitomi, Munetake ^{[3
]}

Morioka, Motohiro ^{[3
]}

Murai, Yoshinaka ^{[2
]}

Tanaka, Eiichiro ^{[2
]}

机构：

[1] Mahidol Univ, Dept Pharmacol, Fac Dent, Bangkok 10400, Thailand

[2] Kurume Univ, Sch Med, Div Brain Sci, Dept Physiol, Kurume, Fukuoka 8300011, Japan

[3] Kurume Univ, Sch Med, Dept Neurosurg, Kurume, Fukuoka 8300011, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 07期

关键词：

edaravone; cardiovascular disease; free radical scavenger; TRANSIENT FOCAL ISCHEMIA; ENDOTHELIAL NITRIC-OXIDE; PERMEABILITY TRANSITION PORE; OXYGEN-FREE-RADICALS; MOBILITY GROUP BOX-1; OXIDATIVE STRESS; REPERFUSION INJURY; CEREBRAL-ISCHEMIA; NAD(P)H OXIDASE; IN-VITRO;

D O I：

10.3390/ijms140713909

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardial infarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosis. This review evaluates the potential of edaravone for treatment of cardiovascular disease, and covers clinical and experimental studies conducted between 1984 and 2013. We propose that edaravone, which scavenges free radicals, may offer a novel option for treatment of cardiovascular diseases. However, additional clinical studies are necessary to verify the efficacy of edaravone.

引用

页码：13909 / 13930

页数：22

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