Platelets in the onset of atherosclerosis

被引：45

作者：

Gawaz, M ^{[1
]}

机构：

[1] Univ Tubingen, Med Klin 3, D-72076 Tubingen, Germany

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2006年 / 36卷 / 02期

关键词：

platelets; atherosclerosis; adhesion; inflammation;

D O I：

10.1016/j.bcmd.2005.12.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Beyond their role in hemostasis and thrombosis platelets are critically involved in the onset of atherosclerosis. Platelets represent an important linkage between inflammation, and atherogenesis. Platelets interact with inflammatory cells including leukocytes and endothelium. These interactions lead to leukocyte recruitment towards the vascular wall, initiating extravasation of circulating mononuclear cells and foam cell generation. Inflammatory processes within the arterial wall result in development of atherosclerotic lesions and atheroprogression. Inhibition of platelet interaction with the arterial wall results in attenuation of atherosclerosis and may be a novel therapeutic strategy in treatment of high-risk patients. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：206 / 210

页数：5

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