T-cell function in newborn mice and humans

被引：239

作者：

Adkins, B ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Immunol & Microbiol, Miami, FL 33136 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(99)01473-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neonates mount poor immune responses, and if has been assumed that neonatal T cells differ qualitatively from adult T cells. Here, Becky Adkins discusses this issue ill the light of recent data indicating that T cells in neonates ave developmentally mature in their capacity to mount protective Th1-type and cytotoxic T lymphocyte responses.

引用

页码：330 / 335

页数：6

共 61 条

[21]

2-P

[22] DIFFERENTIATION OF T-CELL LYMPHOKINE GENE-EXPRESSION - THE INVITRO ACQUISITION OF T-CELL MEMORY [J].

EHLERS, S ;

SMITH, KA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (01) :25-36

[23] Umbilical cord blood contains normal frequencies of cytotoxic T-lymphocyte precursors (ctlp) and helper T-lymphocyte precursors against noninherited maternal antigens and noninherited paternal antigens [J].

Falkenburg, JHF ;

vanLuxemburgHeijs, SAP ;

Lim, FTH ;

Kanhai, HHH ;

Willemze, R .

ANNALS OF HEMATOLOGY, 1996, 72 (04) :260-264

[24] Induction of T(H)1 and T(H)2 immunity in neonatal mice [J].

Forsthuber, T ;

Yip, HC ;

Lehmann, PV .

SCIENCE, 1996, 271 (5256) :1728-1730

[25] DECREASED EXPRESSION OF THE LIGAND FOR CD40 IN NEWBORN LYMPHOCYTES [J].

FULEIHAN, R ;

AHERN, D ;

GEHA, RS .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (08) :1925-1928

[26] The role of CD40 ligand in costimulation and T-cell activation [J].

Grewal, IS ;

Flavell, RA .

IMMUNOLOGICAL REVIEWS, 1996, 153 :85-106

[27]

HARRIS DT, 1994, BLOOD CELLS, V20, P560

[28] PHENOTYPIC AND FUNCTIONAL IMMATURITY OF HUMAN UMBILICAL-CORD BLOOD LYMPHOCYTES-T [J].

HARRIS, DT ;

SCHUMACHER, MJ ;

LOCASCIO, J ;

BESENCON, FJ ;

OLSON, GB ;

DELUCA, D ;

SHENKER, L ;

BARD, J ;

BOYSE, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10006-10010

[29] SELECTIVE INDUCTION OF INTERLEUKIN-4-PRODUCING AND INTERFERON-GAMMA-PRODUCING T-CELLS FROM CORD-BLOOD NAIVE T-CELLS - EFFECTS OF COSTIMULATORY SIGNALING THROUGH CD28 [J].

KATAMURA, K ;

TABATA, Y ;

OSHIMA, Y ;

SHINTAKU, N ;

YAMAUCHI, Y ;

MAYUMI, M .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 106 (02) :101-106

[30]

KEEVER CA, 1995, BONE MARROW TRANSPL, V15, P407

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