Non-antioxidant molecular functions of α-tocopherol (vitamin E)

被引：237

作者：

Azzi, A ^{[1
]}

Ricciarelli, R

Zingg, JM

机构：

[1] Univ Bern, Inst Biochem & Mol Biol, Buhlstr 28, CH-3012 Bern, Switzerland

[2] Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy

来源：

FEBS LETTERS | 2002年 / 519卷 / 1-3期

关键词：

alpha-tocopherol; non-antioxidant mechanism; protein kinase C; cell proliferation; gene expression; platelet aggregation; oxygen burst;

D O I：

10.1016/S0014-5793(02)02706-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by alpha-tocopherol was first described by our group. Later, alpha-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. alpha-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：8 / 10

页数：3

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