The effect of age on expression of endogenous plasminogen activators after focal cerebral ischemia in mice

被引：8

作者：

Ahn, MY

Zhang, ZG

Zhang, L

Chopp, M

机构：

[1] Soonchunhyang Univ Hosp, Dept Neurol, Seoul 140743, South Korea

[2] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA

[3] Oakland Univ, Dept Phys, Rochester, MI 48309 USA

来源：

BRAIN RESEARCH | 1999年 / 833卷 / 01期

关键词：

t-PA; u-PA; age; middle cerebral artery occlusion; mouse;

D O I：

10.1016/S0006-8993(99)01430-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We measured urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) activity in the brain of 2-3 month old and 6-8 month old mice subjected to 4 h of middle cerebral artery (MCA) occlusion, t-PA activity was present in all non-ischemic and ischemic young mouse brain. In contrast, t-PA activity was present in 46.7% of non-ischemic middle aged mouse brain and in 44.4% of ischemic middle aged mouse brain. u-PA activity was present in all young and middle aged non-ischemic brains. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：112 / 116

页数：5

共 22 条

[1] UROKINASE-TYPE PLASMINOGEN-ACTIVATOR - PROENZYME, RECEPTOR, AND INHIBITORS [J].