PHYSIOLOGICAL CONSEQUENCES OF LOSS OF PLASMINOGEN-ACTIVATOR GENE-FUNCTION IN MICE

被引：920

作者：

CARMELIET, P

SCHOONJANS, L

KIECKENS, L

REAM, B

DEGEN, J

BRONSON, R

DEVOS, R

VANDENOORD, JJ

COLLEN, D

MULLIGAN, RC

机构：

[1] CATHOLIC UNIV LEUVEN, CTR MOLEC & VASC BIOL, B-3000 LOUVAIN, BELGIUM

[2] MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA

[3] MIT, DEPT BIOL, CAMBRIDGE, MA 02142 USA

[4] UNIV CINCINNATI, CHILDRENS HOSP RES FDN, CINCINNATI, OH 45229 USA

[5] TUFTS UNIV, SCH VET MED, BOSTON, MA 02111 USA

[6] CATHOLIC UNIV LEUVEN, HISTO & CYTOCHEM LAB, B-3000 LOUVAIN, BELGIUM

来源：

NATURE | 1994年 / 368卷 / 6470期

关键词：

D O I：

10.1038/368419a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.

引用

页码：419 / 424

页数：6

共 38 条

[1] THE FIBRIN PLATE METHOD FOR ESTIMATING FIBRINOLYTIC ACTIVITY [J].