Cancer as a complex genetic trait: Tumor susceptibility in humans and mouse models

被引:109
作者
Balmain, A [1 ]
机构
[1] Univ Calif San Francisco, Dept Biochem & Biophys, Ctr Comprehens Canc, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0092-8674(02)00622-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.
引用
收藏
页码:145 / 152
页数:8
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