The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample

被引：30

作者：

Crawford, F

Town, T

Freeman, M

Schinka, J

Gold, M

Duara, R

Mullan, M

机构：

[1] Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

[2] Bristol Myers Squibb Co, Princeton, NJ 08543 USA

[3] Univ Miami, Mt Sinai Memory Disorder Clin, Miami, FL 33152 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 270卷 / 03期

关键词：

Alzheimer's disease; alpha-2; macroglobulin; genetic association; beta-amyloid;

D O I：

10.1016/S0304-3940(99)00470-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genetic association has recently been reported between alleles in the alpha-2-macroglobulin (A2M) gene and the occurrence of Alzheimer's disease (AD) in fami I ia I and sporadic samples. We have investigated the A2M intronic deletion polymorphism in a case-control study of 295 unrelated clinic and community-based AD cases, and compared these to a sample of 113 unrelated control individuals recruited as part of an epidemiological study. Our results show no association between A2M and AD in either case sample. Furthermore, A2M is not predictive of AD in an interactive fashion when considering APOE, race or gender, in a subset of our larger sample we have also investigated the A2M Val1000Ile polymorphism, and again find no evidence for association. We conclude that there is no genetic association between A2M and AD in our case-control sample. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：133 / 136

页数：4

共 20 条

[11]

Narita M, 1997, J NEUROCHEM, V69, P1904

[12] Complete genomic screen in late-onset familial Alzheimer disease - Evidence for a new locus on chromosome 12 [J].

PericakVance, MA ;

Bass, MP ;

Yamaoka, LH ;

Gaskell, PC ;

Scott, WK ;

Terwedow, HA ;

Menold, MM ;

Conneally, PM ;

Small, GW ;

Vance, JM ;

Saunders, AM ;

Roses, AD ;

Haines, JL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (15) :1237-1241

[13] MULTIPLE, DIVERSE SENILE PLAQUE-ASSOCIATED PROTEINS ARE LIGANDS OF AN APOLIPOPROTEIN-E RECEPTOR, THE ALPHA(2)-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN [J].

REBECK, GW ;

HARR, SD ;

STRICKLAND, DK ;

HYMAN, BT .

ANNALS OF NEUROLOGY, 1995, 37 (02) :211-217

[14] Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity [J].

Rogaeva, E ;

Premkumar, S ;

Song, YQ ;

Sorbi, S ;

Brindle, N ;

Paterson, A ;

Duara, R ;

Levesque, G ;

Yu, G ;

Nishimura, M ;

Ikeda, M ;

O'Toole, C ;

Kawarai, T ;

Jorge, R ;

Vilarino, D ;

Bruni, AC ;

Farrer, LA ;

St George-Hyslop, PH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (07) :614-618

[15] An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease [J].

Rogaeva, EA ;

Premkumar, S ;

Grubber, J ;

Serneels, L ;

Scott, WK ;

Kawarai, T ;

Song, YQ ;

Hill, DM ;

Abou-Donia, SM ;

Martin, ER ;

Vance, JJ ;

Yu, G ;

Orlacchio, A ;

Pei, Y ;

Nishimura, M ;

Supala, A ;

Roberge, B ;

Saunders, AM ;

Roses, AD ;

Schmechel, D ;

Crane-Gatherum, A ;

Sorbi, S ;

Bruni, A ;

Small, GW ;

Conneally, PM ;

Haines, JL ;

Van Leuven, F ;

St George-Hyslop, PH ;

Farrer, LA ;

Pericak-Vance, MA .

NATURE GENETICS, 1999, 22 (01) :19-21

[16] α-2 macroglobulin gene and Alzheimer disease [J].

Rudrasingham, V ;

Wavrant-De Vrièze, F ;

Lambert, JC ;

Chakraverty, S ;

Kehoe, P ;

Crook, R ;

Amouyel, P ;

Wu, W ;

Rice, F ;

Pérez-Tur, J ;

Frigard, B ;

Morris, JC ;

Carty, S ;

Petersen, R ;

Cottel, D ;

Tunstall, N ;

Holmans, P ;

Lovestone, S ;

Chartier-Harlin, MC ;

Goate, A ;

Hardy, J ;

Owen, MJ ;

Williams, J .

NATURE GENETICS, 1999, 22 (01) :17-19

[17] IMMUNOHISTOCHEMICAL STUDY OF ALPHA-2 MACROGLOBULIN RECEPTOR IN ALZHEIMER AND CONTROL POSTMORTEM HUMAN BRAIN [J].

TOOYAMA, I ;

KAWAMATA, T ;

AKIYAMA, H ;

MOESTRUP, SK ;

GLIEMANN, J ;

MCGEER, PL .

MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1993, 18 (1-2) :153-160

[18] No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease [J].

Wavrant-DeVrièze, F ;

Rudrasingham, V ;

Lambert, JC ;

Chakraverty, S ;

Kehoe, P ;

Crook, R ;

Amouyel, P ;

Wu, W ;

Holmans, P ;

Rice, F ;

Pérez-Tur, J ;

Frigard, B ;

Morris, JC ;

Carty, S ;

Cottel, D ;

Tunstall, N ;

Lovestone, S ;

Petersen, RC ;

Chartier-Harlin, MC ;

Goate, A ;

Owen, MJ ;

Williams, J ;

Hardy, J .

NEUROSCIENCE LETTERS, 1999, 262 (02) :137-139

[19] APOLIPOPROTEIN-E GENOTYPING BY ONE-STAGE PCR [J].

WENHAM, PR ;

PRICE, WH ;

BLUNDELL, G .

LANCET, 1991, 337 (8750) :1158-1159

[20] CYTOKINE INDEXES IN ALZHEIMERS TEMPORAL CORTEX - NO CHANGES IN MATURE IL-1-BETA OR IL-1RA BUT INCREASES IN THE ASSOCIATED ACUTE-PHASE PROTEINS IL-6, ALPHA-2-MACROGLOBULIN AND C-REACTIVE PROTEIN [J].

WOOD, JA ;

WOOD, PL ;

RYAN, R ;

GRAFFRADFORD, NR ;

PILAPIL, C ;

ROBITAILLE, Y ;

QUIRION, R .

BRAIN RESEARCH, 1993, 629 (02) :245-252

← 1 2 →