An integrated map with cosmid/PAC contigs of a 4-mb Down syndrome critical region

被引：44

作者：

Osoegawa, K

Susukida, R

Okano, S

Kudoh, J

Minoshima, S

Shimizu, N

DeJong, PJ

Groet, J

Ives, J

Lehrach, H

Nizetic, D

Soeda, E

机构：

[1] RIKEN,INST PHYS & CHEM RES,GENE BANK,TSUKUBA,IBARAKI 305,JAPAN

[2] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,SHINJUKU KU,TOKYO 160,JAPAN

[3] ROSWELL PK CANC INST,BUFFALO,NY 14263

[4] UNIV LONDON,SCH PHARM,CTR APPL MOLEC BIOL,LONDON WC1N 1AX,ENGLAND

[5] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

来源：

GENOMICS | 1996年 / 32卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1006/geno.1996.0132

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band, We present here a high-resolution physical map with megabase-sized cosmid/PAC contigs, This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing. (C) 1996 Academic Press, Inc.

引用

页码：375 / 387

页数：13

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