CONTINUUM OF OVERLAPPING CLONES SPANNING THE ENTIRE HUMAN CHROMOSOME-21Q

被引：476

作者：

CHUMAKOV, I

RIGAULT, P

GUILLOU, S

OUGEN, P

BILLAUT, A

GUASCONI, G

GERVY, P

LEGALL, I

SOULARUE, P

GRINAS, L

BOUGUELERET, L

BELLANNECHANTELOT, C

LACROIX, B

BARILLOT, E

GESNOUIN, P

POOK, S

VAYSSEIX, G

FRELAT, G

SCHMITZ, A

SAMBUCY, JL

BOSCH, A

ESTIVILL, X

WEISSENBACH, J

VIGNAL, A

RIETHMAN, H

COX, D

PATTERSON, D

GARDINER, K

HATTORI, M

SAKAKI, Y

ICHIKAWA, H

OHKI, M

LEPASLIER, D

HEILIG, R

ANTONARAKIS, S

COHEN, D

机构：

[1] CTR ETUD POLYMORPHISME HUMAIN,27 RUE JULIETTE DODU,F-75010 PARIS,FRANCE

[2] GENETHON,F-91002 EVRY,FRANCE

[3] CEA,F-92260 FONTENAY ROSES,FRANCE

[4] HOSP DURAN & REYNALS,INST RECERCA ONCOL,E-08907 BARCELONA,SPAIN

[5] INST PASTEUR,CNRS,URA 1445,F-75724 PARIS,FRANCE

[6] UNIV CALIF SAN FRANCISCO,NEUROGENET LAB,SAN FRANCISCO,CA 94143

[7] ELEANOR ROOSEVELT INST,DENVER,CO 80206

[8] WISTAR INST,PHILADELPHIA,PA 19104

[9] UNIV TOKYO,INST MED SCI,TOKYO 108,JAPAN

[10] LAB GENET MOLEC EUCARYOTES,INSERM,U184,STRASBOURG,FRANCE

[11] JOHNS HOPKINS UNIV,SCH MED,CTR MED GENET,BALTIMORE,MD 21205

[12] SAITAMA CANC CTR,RES INST,INA,SAITAMA 362,JAPAN

来源：

NATURE | 1992年 / 359卷 / 6394期

关键词：

D O I：

10.1038/359380a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and ends with subtelomeric loci of 21q. The resulting order of sequence-tagged sites is consistent with other physical and genetic mapping data. This set of overlapping clones will promote our knowledge of the structure of this chromosome and the function of its genes.

引用

页码：380 / 387

页数：8

共 28 条

[1] CONSTRUCTION AND CHARACTERIZATION OF A YEAST ARTIFICIAL CHROMOSOME LIBRARY CONTAINING 7 HAPLOID HUMAN GENOME EQUIVALENTS [J].