Dendritic cell derived cytokines in human natural killer cell cifferentiation anc activation

被引：45

作者：

Chijioke, Obinna ^{[1
]}

Muenz, Christian ^{[1
]}

机构：

[1] Univ Zurich, Inst Expt Immunol, Viral Immunobiol, CH-8057 Zurich, Switzerland

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

基金：

瑞士国家科学基金会;

关键词：

IL-18; IL-12; IL-15; IFN-alpha; immunological synapse; NKp30; DNAM-1; NK CELLS; CROSS-TALK; IFN-GAMMA; T-CELLS; LYMPH-NODES; SUPPRESSOR-CELLS; LANGERHANS CELLS; DISTINCT ROLES; DC MATURATION; STEADY-STATE;

D O I：

10.3389/fimmu.2013.00365

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) and natural killer (NK) cells shape each other's functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. Finally, we will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes.

引用

页数：7

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