The Cdx-1 and Cdx-2 homeobox genes in the intestine

被引：170

作者：

Freund, JN ^{[1
]}

Domon-Dell, C ^{[1
]}

Kedinger, M ^{[1
]}

Duluc, I ^{[1
]}

机构：

[1] INSERM, U381, F-67200 Strasbourg, France

来源：

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 1998年 / 76卷 / 06期

关键词：

caudal; epithelial cell proliferation and differentiation; cancer;

D O I：

10.1139/bcb-76-6-957

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past years have witnessed an increasing number of reports relative to homeobox genes in endoderm-derived tissues. In this review, we focus on the caudal-related Cdx-1 and Cdx-2 homeobox genes to give an overview of the in vivo, in vitro, and ex vivo approaches that emphasize their primary role in intestinal development and in the control of intestinal cell proliferation, differentiation, and identity. The participation of these genes in colon tumorigenesis and their identification as important actors of the oncogenic process are also discussed.

引用

收藏

页码：957 / 969

页数：13

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