Lost in transdifferentiation

被引：37

作者：

Hoofnagle, MH ^{[1
]}

Wamhoff, BR ^{[1
]}

Owens, GK ^{[1
]}

机构：

[1] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 09期

关键词：

D O I：

10.1172/JCI200421761

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

What are the true origins of the smooth muscle cells (SMCs) present in the intimal lesions of transplant arteriosclerosis? A new study in the JCI shows that Sca-1(+) cells purified from the mouse aortic root can migrate through an irradiated vein graft to the neointima of the vessel and transdifferentiate to express the early SMC differentiation marker gene SM22 (see the related article beginning on page 1258). Do Sca-1(+) cells transdifferentiate into SMC-like cells, or is activation of SMC marker genes a consequence of fusion of these cells with preexisting SMCs, a possibility raised by results of studies of adult stem cells in animal models of liver regeneration (see the related article beginning on page 1266)? Or could this be bona fide transdifferentiation that recapitulates the pathologic processes in humans?.

引用

页码：1249 / 1251

页数：3

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