Genome sequence of the Brown Norway rat yields insights into mammalian evolution

被引：1563

作者：

Gibbs, RA

Weinstock, GM

Metzker, ML

Muzny, DM

Sodergren, EJ

Scherer, S

Scott, G

Steffen, D

Worley, KC

Burch, PE

Okwuonu, G

Hines, S

Lewis, L

DeRamo, C

Delgado, O

Dugan-Rocha, S

Miner, G

Morgan, M

Hawes, A

Gill, R

Holt, RA

Adams, MD

Amanatides, PG

Baden-Tillson, H

Barnstead, M

Chin, S

Evans, CA

Ferriera, S

Fosler, C

Glodek, A

Gu, ZP

Jennings, D

Kraft, CL

Nguyen, T

Pfannkoch, CM

Sitter, C

Sutton, GG

Venter, JC

Woodage, T

Smith, D

Lee, HM

Gustafson, E

Cahill, P

Kana, A

Doucette-Stamm, L

Weinstock, K

Fechtel, K

Weiss, RB

Dunn, DM

Green, ED

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA

[2] British Columbia Canc Agcy, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada

[3] Celera, Rockville, MD 20850 USA

[4] Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Sch Med, Ctr Computat Gen, Cleveland, OH 44106 USA

[6] DSM Pharmaceut Inc, Greenville, NC 27834 USA

[7] Inst Biol Energy Alternat, Rockville, MD 20850 USA

[8] Intronn Inc, Gaithersburg, MD 20878 USA

[9] Ctr Advancement Gen TCAG, Rockville, MD 20850 USA

[10] Avalon Pharmaceut, Germantown, MD 20876 USA

[11] NIAID, Basic Immunol Branch, Div Allergy Immunol & Transplantat, NIH,DHHS, Bethesda, MD 20892 USA

[12] DynPort Vaccine Co LLC, Frederick, MD 21702 USA

[13] Genome Therapeut Corp, Waltham, MA 02453 USA

[14] Agencourt Biosci Corp, Beverly, MA 01915 USA

[15] Univ Utah, Dept Human Genet, Salt Lake City, UT 84112 USA

[16] NHGRI, NIH, Intramural Sequencing Ctr, NISC, Bethesda, MD 20892 USA

[17] NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA

[18] Childrens Hosp, Oakland Res Inst, BACPAC Resources, Oakland, CA 94609 USA

[19] Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA

[20] Inst Gen Res, Rockville, MD 20850 USA

[21] Affymetrix, Oakland, CA 94608 USA

[22] Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

[23] EBI, Hinxton CB10 1SD, Cambs, England

[24] European Mol Biol Lab, D-69117 Heidelberg, Germany

[25] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[26] Fraunhofer Chalmers Res Ctr Ind Math, S-41288 Gothenburg, Sweden

[27] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[28] Incyte Corp, Palo Alto, CA 94304 USA

[29] Univ Pompeu Fabra, Inst Municipal Invest Med, Grp Rec Informat Biomedia, Barcelona 08003, Spain

[30] Ctr Regulacio Gen, Programa Bioinformat & Gen, Barcelona 08003, Spain

[31] Inst Syst Biol, Computat Biol Grp, Seattle, WA 98103 USA

[32] Univ Calif Berkeley, Lawrence Berkeley Lab, Gen Div, Berkeley, CA 94720 USA

[33] US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA

[34] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

[35] Med Coll Wisconsin, Human & Mol Genet Ctr, Bioinformat Res Ctr, Milwaukee, WI 53226 USA

[36] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[37] Med Coll Wisconsin, Bioinformat Res Ctr, Rat Genome Database, Milwaukee, WI 53226 USA

[38] Univ Oxford, MRC, Funct Genet Unit, Dept Human Anat & Genet, Oxford OX1 3QX, England

[39] MWG Biotech, D-85560 Ebersberg, Germany

[40] Penn State Univ, Dept Biol, Huck Inst Life Sci, Ctr Comparat Gen & Bioinformat, University Pk, PA 16802 USA

[41] Penn State Univ, Dept Stat, University Pk, PA 16802 USA

[42] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

[43] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA

[44] Penn State Univ, Dept Hlth Evaluat Sci, University Pk, PA 16802 USA

[45] F Hoffmann La Roche Ltd, Roche Genet & Roche Ctr Med Gen, CH-4070 Basel, Switzerland

[46] Sanger Inst, Hinxton CB10 1SA, Cambs, England

[47] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[48] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[49] Stanford Univ, Dept Comp Sci, James H Clark Ctr S256, Stanford, CA 94305 USA

[50] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA

来源：

NATURE | 2004年 / 428卷 / 6982期

关键词：

D O I：

10.1038/nature02426

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

引用

页码：493 / 521

页数：29

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