The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

被引:120
作者
Tame, JRH
Sleigh, SH
Wilkinson, AJ
Ladbury, JE
机构
[1] UNIV YORK, DEPT CHEM, YORK YO1 5DD, N YORKSHIRE, ENGLAND
[2] UNIV OXFORD, OXFORD CTR MOL SCI, NEW CHEM LAB, OXFORD OX1 3QT, ENGLAND
来源
NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 12期
关键词
D O I
10.1038/nsb1296-998
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Buried water molecules play a pivotal structural and energetic role in mediating interactions between a bacterial oligopeptide transporter protein and its ligands.
引用
收藏
页码:998 / 1001
页数:4
相关论文
共 23 条
[11]   A NEW CLASS OF SYNTHETIC ANTIBACTERIALS ACTING ON LIPOPOLYSACCHARIDE BIOSYNTHESIS [J].
HAMMOND, SM ;
CLAESSON, A ;
JANSSON, AM ;
LARSSON, LG ;
PRING, BG ;
TOWN, CM ;
EKSTROM, B .
NATURE, 1987, 327 (6124) :730-732
[12]   Role of hydration and water structure in biological and colloidal interactions [J].
Israelachvili, J ;
Wennerstrom, H .
NATURE, 1996, 379 (6562) :219-225
[13]   A THERMODYNAMIC STUDY OF THE TRP REPRESSOR-OPERATOR INTERACTION [J].
LADBURY, JE ;
WRIGHT, JG ;
STURTEVANT, JM ;
SIGLER, PB .
JOURNAL OF MOLECULAR BIOLOGY, 1994, 238 (05) :669-681
[14]   Sensing the heat: The application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions [J].
Ladbury, JE ;
Chowdhry, BZ .
CHEMISTRY & BIOLOGY, 1996, 3 (10) :791-801
[15]   SUBSTRATE-SPECIFICITY AND AFFINITY OF A PROTEIN MODULATED BY BOUND WATER-MOLECULES [J].
QUIOCHO, FA ;
WILSON, DK ;
VYAS, NK .
NATURE, 1989, 340 (6232) :404-407
[16]   Atomic structures and function of periplasmic receptors for active transport and chemotaxis [J].
Quiocho, Florante A. .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1991, 1 (06) :922-933
[17]   PROTEIN SIDE-CHAIN CONFORMATIONAL ENTROPY DERIVED FROM FUSION DATA - COMPARISON WITH OTHER EMPIRICAL SCALES [J].
STERNBERG, MJE ;
CHICKOS, JS .
PROTEIN ENGINEERING, 1994, 7 (02) :149-155
[18]   THE THERMODYNAMIC EFFECTS OF PROTEIN MUTATIONS [J].
STURTEVANT, JM .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1994, 4 (01) :69-78
[19]   The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands [J].
Tame, JRH ;
Dodson, EJ ;
Murshudov, G ;
Higgins, CF ;
Wilkinson, AJ .
STRUCTURE, 1995, 3 (12) :1395-1406
[20]  
TAME JRH, 1994, SCIENCE, V264, P1578, DOI 10.1126/science.8202710