Extending the time window for thrombolysis: Evidence from acute stroke trials

被引：23

作者：

Rowley, HA ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Radiol, Madison, WI 53792 USA

来源：

NEUROIMAGING CLINICS OF NORTH AMERICA | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.nic.2005.08.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Data from intravenous tissue plasminogen activator studies have shown rapidly diminishing clinical benefit beyond 3 hours when noncontrast CT is used for treatment triage. Newer trials, such as the Desmoteplase in Acute Ischemic Stroke trial, have now successfully pushed the time window out to 9 hours using the concept of penumbral imaging and treatment of the perfusion-diffusion mismatch. Advanced imaging with CT or MR imaging protocols is providing a means for rational physiologic selection and outcomes assessment in stroke treatment.

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页码：575 / +

页数：14

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