Sonic hedgehog in the nervous system: functions, modifications and mechanisms

被引：117

作者：

Ho, KS

Scott, MP

机构：

[1] Stanford Univ, Sch Med, Dept Dev Biol, Howard Hughes Med Inst,Beckman Ctr B300, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Dev Biol, Dept Genet, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-4388(02)00290-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Signaling by Sonic hedgehog (Shh) controls important developmental processes, including dorsoventral neural tube patterning, neural stem cell proliferation, and neuronal and glial cell survival. Shh signaling involves lipid modifications to Shh itself, as well as changes in protein subcellular localization. Recent advances have revealed the importance of palmitoylation and acylation of Shh on its potency and migration capacity. Subsequent trafficking and organelle sorting in the Shh signaling pathway have been observed; these observations offer a new dimension to our understanding of downstream signal transduction events.

引用

页码：57 / 63

页数：7

共 61 条

[1] Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death [J].