STRING 8-a global view on proteins and their functional interactions in 630 organisms

被引：1950

作者：

Jensen, Lars J. ^{[1
,2
]}

Kuhn, Michael ^{[1
]}

Stark, Manuel ^{[3
,4
]}

Chaffron, Samuel ^{[3
,4
]}

Creevey, Chris ^{[1
]}

Muller, Jean ^{[1
]}

Doerks, Tobias ^{[1
]}

Julien, Philippe ^{[5
]}

Roth, Alexander ^{[3
,4
]}

Simonovic, Milan ^{[3
,4
]}

Bork, Peer ^{[1
,6
]}

von Mering, Christian ^{[3
,4
]}

机构：

[1] European Mol Biol Lab, Heidelberg, Germany

[2] Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, DK-1168 Copenhagen, Denmark

[3] Univ Zurich, Inst Mol Biol, CH-8006 Zurich, Switzerland

[4] Univ Zurich, Swiss Inst Bioinformat, CH-8006 Zurich, Switzerland

[5] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

[6] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

INTERACTION NETWORKS; INTERACTION DATABASE; BIOLOGICAL NETWORKS; GENOMIC DATA; UPDATE; PREDICTION; ASSOCIATIONS; ENVIRONMENT; SOFTWARE; RESOURCE;

D O I：

10.1093/nar/gkn760

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein-protein interactions, including both physical and functional interactions. It weights and integrates information from numerous sources, including experimental repositories, computational prediction methods and public text collections, thus acting as a meta-database that maps all interaction evidence onto a common set of genomes and proteins. The most important new developments in STRING 8 over previous releases include a URL-based programming interface, which can be used to query STRING from other resources, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures. Version 8.0 of STRING covers about 2.5 million proteins from 630 organisms, providing the most comprehensive view on protein-protein interactions currently available. STRING can be reached at http://string-db.org/.

引用

页码：D412 / D416

页数：5

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