p38 and Chk1 kinases:: different conductors for the G2/M checkpoint symphony

被引：156

作者：

Bulavin, DV ^{[1
]}

Amundson, SA ^{[1
]}

Fornace, AJ ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, Gene Response Sect, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(01)00270-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mechanism controlling G(2)/M checkpoint activation after DNA damage was thought to be mediated primarily by nuclear Chk1/Chk2 kinases. Recent evidence indicates that this checkpoint is more complex, involving at least two different biochemical systems that target the Cdc25B and Cdc25C phosphatases. Following genotoxic stress, different kinases integrate signaling from the damaged DNA and other damaged cellular components to regulate Cdc25 inactivation. Our current model for G2/M checkpoint activation after genotoxic stress is discussed emphasizing the roles for Chk1 and p38 kinases in checkpoint regulation.

引用

页码：92 / 97

页数：6

共 35 条

[11] DNA damage-induced activation of p53 by the checkpoint kinase Chk2 [J].

Hirao, A ;

Kong, YY ;

Matsuoka, S ;

Wakeham, A ;

Ruland, J ;

Yoshida, H ;

Liu, D ;

Elledge, SJ ;

Mak, TW .

SCIENCE, 2000, 287 (5459) :1824-1827

[12] Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells [J].

Jin, P ;

Gu, Y ;

Morgan, DO .

JOURNAL OF CELL BIOLOGY, 1996, 134 (04) :963-970

[13] Nuclear localization of cyclin B1 controls mitotic entry after DNA damage [J].

Jin, P ;

Hardy, S ;

Morgan, DO .

JOURNAL OF CELL BIOLOGY, 1998, 141 (04) :875-885

[14] Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis [J].

Karlsson, C ;

Katich, S ;

Hagting, A ;

Hoffmann, I ;

Pines, J .

JOURNAL OF CELL BIOLOGY, 1999, 146 (03) :573-583

[15] Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25 [J].

Kumagai, A ;

Dunphy, WG .

GENES & DEVELOPMENT, 1999, 13 (09) :1067-1072

[16] Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase [J].

Kumar, S ;

Jiang, MS ;

Adams, JL ;

Lee, JC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 263 (03) :825-831

[17] Inhibition of p38 MAP kinase as a therapeutic strategy [J].

Lee, JC ;

Kumar, S ;

Griswold, DE ;

Underwood, DC ;

Votta, BJ ;

Adams, JL .

IMMUNOPHARMACOLOGY, 2000, 47 (2-3) :185-201

[18]

Liu QH, 2000, GENE DEV, V14, P1448

[19] Three distinct signalling responses by murine fibroblasts to genotoxic stress [J].

Liu, ZG ;

Baskaran, R ;

LeaChou, ET ;

Wood, LD ;

Chen, Y ;

Karin, M ;

Wang, JYJ .

NATURE, 1996, 384 (6606) :273-276

[20] Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein [J].

Lopez-Girona, A ;

Furnari, B ;

Mondesert, O ;

Russell, P .

NATURE, 1999, 397 (6715) :172-175

← 1 2 3 4 →