Phosphatidylinositol-3-OH kinases are Rab5 effectors

被引:432
作者
Christoforidis, S
Miaczynska, M
Ashman, K
Wilm, M
Zhao, LY
Yip, SC
Waterfield, MD
Backer, JM
Zerial, M
机构
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
[2] European Mol Biol Lab, D-69117 Heidelberg, Germany
[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
[4] UCL, Ludwig Inst Canc Res, London W1P 8BT, England
关键词
D O I
10.1038/12075
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:249 / 252
页数:4
相关论文
共 18 条
[1]   THE SMALL GTPASE RAB5 FUNCTIONS AS A REGULATORY FACTOR IN THE EARLY ENDOCYTIC PATHWAY [J].
BUCCI, C ;
PARTON, RG ;
MATHER, IH ;
STUNNENBERG, H ;
SIMONS, K ;
HOFLACK, B ;
ZERIAL, M .
CELL, 1992, 70 (05) :715-728
[2]   Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains [J].
Burd, CG ;
Emr, SD .
MOLECULAR CELL, 1998, 2 (01) :157-162
[3]   The Rab5 effector EEA1 is a core component of endosome docking [J].
Christoforidis, S ;
McBride, HM ;
Burgoyne, RD ;
Zerial, M .
NATURE, 1999, 397 (6720) :621-625
[4]   A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function [J].
Horiuchi, H ;
Lippe, R ;
McBride, HM ;
Rubino, M ;
Woodman, P ;
Stenmark, H ;
Rybin, V ;
Wilm, M ;
Ashman, K ;
Mann, M ;
Zerial, M .
CELL, 1997, 90 (06) :1149-1159
[5]   Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5 [J].
Jones, AT ;
Mills, IG ;
Scheidig, AJ ;
Alexandrov, K ;
Clague, MJ .
MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (02) :323-332
[6]   EVIDENCE FOR PHOSPHATIDYLINOSITOL 3-KINASE AS A REGULATOR OF ENDOCYTOSIS VIA ACTIVATION OF RAB5 [J].
LI, GP ;
D'SOUZA-SCHOREY, C ;
BARBIERI, MA ;
ROBERTS, RL ;
KLIPPEL, A ;
WILLIAMS, LT ;
STAHL, PD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) :10207-10211
[7]   A novel role for Rab5-GDI in ligand sequestration into calthrin-coated pits [J].
McLauchlan, H ;
Newell, J ;
Morrice, N ;
Osborne, A ;
West, M ;
Smythe, E .
CURRENT BIOLOGY, 1998, 8 (01) :34-45
[8]   EEA1, AN EARLY ENDOSOME-ASSOCIATED PROTEIN - EEA1 IS A CONSERVED ALPHA-HELICAL PERIPHERAL MEMBRANE-PROTEIN FLANKED BY CYSTEINE FINGERS AND CONTAINS A CALMODULIN-BINDING IQ MOTIF [J].
MU, FT ;
CALLAGHAN, JM ;
STEELEMORTIMER, O ;
STENMARK, H ;
PARTON, RG ;
CAMPBELL, PL ;
MCCLUSKEY, J ;
YEO, JP ;
TOCK, EPC ;
TOH, BH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) :13503-13511
[9]   The role of phosphoinositide 3-kinase lipid products in cell function [J].
Rameh, LE ;
Cantley, LC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8347-8350
[10]   Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes [J].
Rapoport, I ;
Miyazaki, M ;
Boll, W ;
Duckworth, B ;
Cantley, LC ;
Shoelson, S ;
Kirchhausen, T .
EMBO JOURNAL, 1997, 16 (09) :2240-2250