Electrical remodeling in atrial fibrillation

被引：64

作者：

Dobrev, D ^{[1
]}

机构：

[1] Tech Univ Dresden, Dept Pharmacol & Toxicol, D-8027 Dresden, Germany

来源：

HERZ | 2006年 / 31卷 / 02期

关键词：

atrial fibrillation; remodeling; ion channels; calcium handling; mechanisms;

D O I：

10.1007/s00059-006-2787-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Electrical remodeling refers to any change in electrical function that promotes atrial fibrillation (AF). A key advance in understanding the mechanisms of AF has been the identification of ion channels, gap junctions and regulators of intracellular Ca2+ homeostasis as the molecular determinants of abnormal atrial electrical activity, and how these are modified in AF. This review focuses on the cellular and molecular basis of altered electrical properties of the atria in AF, with the goal of providing new insights into the potential molecular mechanisms and the identification of putative targets for antiarrhythmic therapy.

引用

页码：108 / 112

页数：5

共 41 条

[31] Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure [J].

Shi, YF ;

Li, DS ;

Tardif, JC ;

Nattel, S .

CARDIOVASCULAR RESEARCH, 2002, 54 (02) :456-461

[32] Intracellular calcium changes and tachycardia-induced contractile dysfunction in canine atrial myocytes [J].

Sun, H ;

Chartier, D ;

Leblanc, N ;

Nattel, S .

CARDIOVASCULAR RESEARCH, 2001, 49 (04) :751-761

[33] Atrial L-type Ca2+ currents and human atrial fibrillation [J].

Van Wagoner, DR ;

Pond, AL ;

Lamorgese, M ;

Rossie, SS ;

McCarthy, PM ;

Nerbonne, JM .

CIRCULATION RESEARCH, 1999, 85 (05) :428-436

[34]

VanWagoner DR, 1997, CIRC RES, V80, P772

[35] Enalapril decreases the incidence of atrial fibrillation in patients with left ventricular dysfunction - Insight from the studies of left ventricular dysfunction (SOLVD) trials [J].

Vermes, E ;

Tardif, JC ;

Bourassa, MG ;

Racine, N ;

Levesque, S ;

White, M ;

Guerra, PG ;

Ducharme, A .

CIRCULATION, 2003, 107 (23) :2926-2931

[36] Defective cardiac ryanodine receptor regulation during atrial fibrillation [J].

Vest, JA ;

Wehrens, XHT ;

Reiken, SR ;

Lehnart, SE ;

Dobrev, D ;

Chandra, P ;

Danilo, P ;

Ravens, U ;

Rosen, MR ;

Marks, AR .

CIRCULATION, 2005, 111 (16) :2025-2032

[37] ATRIAL-FIBRILLATION BEGETS ATRIAL-FIBRILLATION - A STUDY IN AWAKE CHRONICALLY INSTRUMENTED GOATS [J].

WIJFFELS, MCEF ;

KIRCHHOF, CJHJ ;

DORLAND, R ;

ALLESSIE, MA .

CIRCULATION, 1995, 92 (07) :1954-1968

[38] A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation [J].

Xia, M ;

Jin, QF ;

Bendahhou, S ;

He, YS ;

Larroque, MM ;

Chen, YP ;

Zhou, QS ;

Yang, YQ ;

Liu, Y ;

Liu, B ;

Zhu, Q ;

Zhou, YT ;

Lin, J ;

Liang, B ;

Li, L ;

Dong, XJ ;

Pan, ZW ;

Wang, RG ;

Wan, HY ;

Qiu, WQ ;

Xu, WY ;

Eurlings, P ;

Barhanin, J ;

Chen, YH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 332 (04) :1012-1019

[39] Up-regulation of inositol 1,4,5 trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation [J].

Yamada, J ;

Ohkusa, T ;

Nao, T ;

Yano, M ;

Kobayashi, S ;

Hamano, K ;

Esato, K ;

Matsuzaki, M .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (04) :1111-1119

[40]

Yamada M, 1998, PHARMACOL REV, V50, P723

← 1 2 3 4 5 →