A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicusa

被引：13

作者：

Duan, Changling ^{[1
,3
]}

Wang, Yi ^{[2
]}

Ma, Xiaofeng ^{[2
]}

Jiang, Yong ^{[1
]}

Liu, Jianxun ^{[3
]}

Tu, Pengfei ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China

[3] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2012年 / 48卷 / 04期

关键词：

Ophiopogon japonicus; furostanol glycoside; fatty acid synthase; Liliaceae; THUNB; KER-GAWL; STEROIDAL SAPONINS;

D O I：

10.1007/s10600-012-0325-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new furostanol glycoside, named ophiopogonin J (1), was isolated from the fibrous root of Ophiopogon japonicas. The structure of the compound was established as (25R)-26-[(O-beta-D-glucopyranosyl-(1 -> aEuro parts per thousand 2)-beta-D-glucopyranosyl)]-20 alpha -hydroxyfurost-5, 22-diene-3-O-alpha-L-rhamnopyranosyl-(1 -> aEuro parts per thousand 2)-[beta-D-xylopyranosyl(1 -> aEuro parts per thousand 4)]-beta-D-glucopyranoside on the basis of spectroscopic methods, including HR-ESI-MS and 1D and 2D NMR experiments.

引用

页码：613 / 615

页数：3

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