Steroidal saponins from Smilax china and their anti-inflammatory activities

被引：114

作者：

Shao, Bo ^{[1
]}

Guo, Hongzhu ^{[1
]}

Cui, Yajun ^{[1
]}

Ye, Min ^{[1
]}

Han, Jian ^{[1
]}

Guo, Dean ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

PHYTOCHEMISTRY | 2007年 / 68卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Smilax china; Liliaceae; steroidal saponins; smilaxchinoside A-D; anti-inflammatory activities; cyclooxygenase-2; enzyme; tumor necrosis factor alpha;

D O I：

10.1016/j.phytochem.2006.10.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Steroidal saponins, 1, 2, 3 and 4, were isolated from the BuOH extract of Smilax china L., along with 13 known compounds, 5-17. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses and chemical evidence. In the bioassay tests, all compounds showed inhibitory effects on cyclooxygenase-2 enzyme (COX-2) activities at final concentration of 10(-5) M, and only compound 5 showed an inhibitory effect on production of TNF alpha (tumor necrosis factor a) in murine peritoneal macrophages at the same concentration. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：623 / 630

页数：8

共 32 条

[1] Dependence of 1H NMR chemical shifts of geminal protons of glycosyloxy methylene (H2-26) on the orientation of the 27-methyl group of furostane-type steroidal saponins [J].

Agrawal, PK .

MAGNETIC RESONANCE IN CHEMISTRY, 2004, 42 (11) :990-993

[2] C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].

AGRAWAL, PK ;

JAIN, DC ;

GUPTA, RK ;

THAKUR, RS .

PHYTOCHEMISTRY, 1985, 24 (11) :2479-2496

[3] FUROSTANOL OLIGOSIDES FROM TAMUS-COMMUNIS [J].

AQUINO, R ;

BEHAR, I ;

DESIMONE, F ;

DAGOSTINO, M ;

PIZZA, C .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (06) :1096-1101

[4] Steroidal saponins from Smilax officinalis [J].

Bernardo, RR ;

Pinto, AV ;

Parente, JP .

PHYTOCHEMISTRY, 1996, 43 (02) :465-469

[5]

CARMICHAEL J, 1987, CANCER RES, V47, P936

[6]

CHEN DS, 2000, CHIN J HOSP PHARM, V20, P544

[7]

Chen HC, 2005, ACTA CHIM SINICA, V63, P869

[8]

Chen XH, 2004, ACTA PHARMACOL SIN, V25, P927

[9]

CHENGAPPA R, 2002, INDIA TODAY, V27, P38

[10] Maltol glucosides from the tuber of Smilax bockii [J].

Guo, HZ ;

Koike, K ;

Li, W ;

Guo, D ;

Nikaido, T .

PHYTOCHEMISTRY, 2004, 65 (04) :481-484

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