Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis

被引：34

作者：

Wang, Kewei ^{[1
]}

Lin, Bingliang ^{[2
]}

机构：

[1] Univ Illinois, Coll Med Peoria, Dept Surg, Peoria, IL 61605 USA

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou, Peoples R China

来源：

CELLULAR SIGNALLING | 2013年 / 25卷 / 10期

关键词：

IAPs; Caspase; Hepatic apoptosis; NF-KAPPA-B; X-LINKED INHIBITOR; UBIQUITIN LIGASE; ANTAGONISTS INDUCE; CASPASE ACTIVATION; CELL-SURVIVAL; LIVIN/ML-IAP; BIR DOMAIN; ML-IAP; CANCER;

D O I：

10.1016/j.cellsig.2013.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

IAPs are a group of regulatory proteins that are structurally related. Their conserved homologues have been identified in various organisms. In human, eight IAP members have been recognized based on baculoviral IAP repeat (BIR) domains. IAPs are key regulators of apoptosis, cytokinesis and signal transduction. The antiapoptotic property of IAPs depends on their professional role for caspases. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. IAPs impede apoptotic process via membrane receptor-dependent (extrinsic) cascade and mitochondrial dependent (intrinsic) pathway. IAP-mediated apoptosis affects the progression of liver diseases. Therapeutic options of liver diseases may depend on the understanding toward mechanisms of the IAP-mediated apoptosis. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1970 / 1980

页数：11

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