Survivin: A target from brain cancer to neurodegenerative disease

被引：48

作者：

Baratchi, Sara ^{[1
]}

Kanwar, Rupinder K. ^{[1
]}

Kanwar, Jagat R. ^{[1
]}

机构：

[1] Deakin Univ, ITRI, Ctr Biotechnol & Interdisciplinary Biosci BioDeak, LIMBR, Waurn Ponds, Vic 3217, Australia

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 45卷 / 06期

关键词：

BCL-X-L; CHROMOSOMAL PASSENGER COMPLEX; ANTI-APOPTOSIS GENE; NEURONAL CELL-DEATH; NF-KAPPA-B; SPINAL-CORD; MOUSE MODEL; MICROTUBULE DYNAMICS; MOLECULAR-MECHANISM; FUNCTIONAL RECOVERY;

D O I：

10.3109/10409238.2010.516740

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is an important contributing factor during neuronal death in a variety of neurodegenerative disorders, including multiple sclerosis, Parkinson's disease and sciatic nerve injury. Whereas several clinical and preclinical studies have focused on the neuroprotective effects of caspase inhibitors, their clinical benefits are still unclear. Here, we discuss novel alternative strategies to protect neuronal cells from apoptotic death using members of the inhibitors of apoptosis (IAP) family. We specifically review the different roles of survivin, which is an important member of the IAP family that serves a dual role in the inhibition of apoptosis as well as a vital role in mitosis and cell division. Due to the various roles of survivin during cell division and apoptosis, targeting this protein illustrates a new therapeutic window for the treatment of neurodegenerative diseases.</.

引用

页码：535 / 554

页数：20

共 240 条

[1] Modulation of the Ras/Raf/MEK/ERK pathway by Ca2+, and calmodulin [J].