MLL2:: A new mammalian member of the trx/MLL family of genes

被引：82

作者：

FitzGerald, KT ^{[1
]}

Diaz, MO ^{[1
]}

机构：

[1] Loyola Univ, Med Ctr, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA

来源：

GENOMICS | 1999年 / 59卷 / 02期

关键词：

D O I：

10.1006/geno.1999.5860

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded. (C) 1999 Academic Press.

引用

页码：187 / 192

页数：6

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