β1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response

被引：59

作者：

Brakebusch, C ^{[1
]}

Fillatreau, S

Potocnik, AJ

Bungartz, G

Wilhelm, P

Svensson, M

Kearney, P

Körner, H

Gray, D

Fässler, R

机构：

[1] Lund Univ, S-22185 Lund, Sweden

[2] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[3] Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland

[4] Basel Inst Immunol, CH-4005 Basel, Switzerland

[5] Nikolaus Fiebiger Zentrum Mol Med, D-91054 Erlangen, Germany

[6] Act Biotech, S-22007 Lund, Sweden

来源：

IMMUNITY | 2002年 / 16卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(02)00281-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

引用

页码：465 / 477

页数：13

共 62 条

[11] CONSEQUENCES OF LACK OF BETA-1 INTEGRIN GENE-EXPRESSION IN MICE [J].