PAK to the future

被引：342

作者：

Bagrodia, S ^{[1
]}

Cerione, RA ^{[1
]}

机构：

[1] Cornell Univ, Coll Vet Med, Dept Mol Med, Ithaca, NY 14853 USA

来源：

TRENDS IN CELL BIOLOGY | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(99)01618-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the Pak family of serine/threonine kinases serve as targets for the small GTP-binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. Recently, some exciting developments help elaborate the regulation of Pak activity and identify downstream signalling targets. These include the discovery of the Cool/Pix and Cat proteins, which modulate Pak signalling, and downstream kinases that modulate the organization of the actin cytoskeleton or gene expression. We present these recent findings and consider how these new regulators and targets could explain some of the cellular effects that have been attributed to Pak family members.

引用

页码：350 / 355

页数：6

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