Rho kinases in cardiovascular physiology and pathophysiology

被引：568

作者：

Loirand, G ^{[1
]}

Guérin, P ^{[1
]}

Pacaud, P ^{[1
]}

机构：

[1] INSERM, Fac Sci, U 533, Inst Thorax, F-44322 Nantes 3, France

来源：

CIRCULATION RESEARCH | 2006年 / 98卷 / 03期

关键词：

Rho kinase; cardiovascular diseases; Rho-GTP-binding proteins; signal transduction;

D O I：

10.1161/01.RES.0000201960.04223.3c

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Abnormal activation of the RhoA/ROCK pathway has been observed in major cardiovascular disorders such as atherosclerosis, restenosis, hypertension, pulmonary hypertension, and cardiac hypertrophy. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology.

引用

页码：322 / 334

页数：13

共 128 条

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