Regulation and functions of Rho-associated kinase

被引：461

作者：

Amano, M

Fukata, Y

Kaibuchi, K

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cell Pharmacol, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nara Inst Sci & Technol, Div Signal Transduct, Ikoma 6300101, Japan

来源：

EXPERIMENTAL CELL RESEARCH | 2000年 / 261卷 / 01期

基金：

日本学术振兴会;

关键词：

Rho; Rho-associated kinase (Rho-kinase); myosin-binding subunit (MBS); myosin; actin; Ezrin/radixin/moesin (ERM); adducin; intermediate filament; LIM-kinase; collapsin response mediator protein-2 (CRMP2);

D O I：

10.1006/excr.2000.5046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase. (C) 2000 Academic Press.

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收藏

页码：44 / 51

页数：8

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