Diversity of CRISPR-Cas immune systems and molecular machines

被引：64

作者：

Barrangou, Rodolphe ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA

来源：

GENOME BIOLOGY | 2015年 / 16卷

关键词：

GUIDED SURVEILLANCE COMPLEX; IN-VITRO RECONSTITUTION; R-LOOP FORMATION; CRYSTAL-STRUCTURE; RNA CLEAVAGE; CMR COMPLEX; ACQUIRED-RESISTANCE; SPACER ACQUISITION; ESCHERICHIA-COLI; DNA INTERFERENCE;

D O I：

10.1186/s13059-015-0816-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

引用

页数：11

共 162 条

[51] Genetic Characterization of Antiplasmid Immunity through a Type III-A CRISPR-Cas System [J].

Hatoum-Aslan, Asma ;

Maniv, Inbal ;

Samai, Poulami ;

Marraffini, Luciano A. .

JOURNAL OF BACTERIOLOGY, 2014, 196 (02) :310-317

[52] Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA [J].

Haurwitz, Rachel E. ;

Sternberg, Samuel H. ;

Doudna, Jennifer A. .

EMBO JOURNAL, 2012, 31 (12) :2824-2832

[53] Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease [J].

Haurwitz, Rachel E. ;

Jinek, Martin ;

Wiedenheft, Blake ;

Zhou, Kaihong ;

Doudna, Jennifer A. .

SCIENCE, 2010, 329 (5997) :1355-1358

[54] Germ Warfare in a Microbial Mat Community: CRISPRs Provide Insights into the Co-Evolution of Host and Viral Genomes [J].

Heidelberg, John F. ;

Nelson, William C. ;

Schoenfeld, Thomas ;

Bhaya, Devaki .

PLOS ONE, 2009, 4 (01)

[55] Cas9 specifies functional viral targets during CRISPR-Cas adaptation [J].

Heler, Robert ;

Samai, Poulami ;

Modell, Joshua W. ;

Weiner, Catherine ;

Goldberg, Gregory W. ;

Bikard, David ;

Marraffini, Luciano A. .

NATURE, 2015, 519 (7542) :199-+

[56] Adapting to new threats: the generation of memory by CRISPR-Cas immune systems [J].

Heler, Robert ;

Marraffini, Luciano A. ;

Bikard, David .

MOLECULAR MICROBIOLOGY, 2014, 93 (01) :1-9

[57] Enabling functional genomics with genome engineering [J].

Hilton, Isaac B. ;

Gersbach, Charles A. .

GENOME RESEARCH, 2015, 25 (10) :1442-1455

[58] Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers [J].

Hilton, Isaac B. ;

D'Ippolito, Anthony M. ;

Vockley, Christopher M. ;

Thakore, Pratiksha I. ;

Crawford, Gregory E. ;

Reddy, Timothy E. ;

Gersbach, Charles A. .

NATURE BIOTECHNOLOGY, 2015, 33 (05) :510-U225

[59] CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference [J].

Hochstrasser, Megan L. ;

Taylor, David W. ;

Bhat, Prashant ;

Guegler, Chantal K. ;

Sternberg, Samuel H. ;

Nogales, Eva ;

Doudna, Jennifer A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (18) :6618-6623

[60] Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus [J].

Horvath, Philippe ;

Romero, Dennis A. ;

Coute-Monvoisin, Anne-Claire ;

Richards, Melissa ;

Deveau, Helene ;

Moineau, Sylvain ;

Boyaval, Patrick ;

Fremaux, Christophe ;

Barrangou, Rodolphe .

JOURNAL OF BACTERIOLOGY, 2008, 190 (04) :1401-1412

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