Diversity of CRISPR-Cas immune systems and molecular machines

被引：64

作者：

Barrangou, Rodolphe ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA

来源：

GENOME BIOLOGY | 2015年 / 16卷

关键词：

GUIDED SURVEILLANCE COMPLEX; IN-VITRO RECONSTITUTION; R-LOOP FORMATION; CRYSTAL-STRUCTURE; RNA CLEAVAGE; CMR COMPLEX; ACQUIRED-RESISTANCE; SPACER ACQUISITION; ESCHERICHIA-COLI; DNA INTERFERENCE;

D O I：

10.1186/s13059-015-0816-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

引用

页数：11

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